The effect of CPAP therapy on insulin-like growth factor and cognitive functions in obstructive sleep apnea patients

Kanbay A., Demir N. C., TUTAR N., Kostek O., Simsek Z. O., Buyukoglan H., ...More

CLINICAL RESPIRATORY JOURNAL, vol.11, no.4, pp.506-513, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1111/crj.12365
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.506-513
  • Erciyes University Affiliated: Yes


ObjectivesCognitive impairment is common among patients with obstructive sleep apnea syndrome (OSAS). In this study, we aimed to investigate the effect of continuous positive airway pressure (CPAP) therapy on serum insulin-like growth factor-1 (IGF-1) levels and cognitive functions in patients with OSAS.Patient/Methods: Thirty-three patients with newly diagnosed OSAS and 17 healthy-control subjects enrolled in the study. All individuals completed the mini-mental state examination (MMSE) to evaluate cognitive function. Blood samples were taken at the end of the polysomnography in the morning and the same procedures were repeated 3 months after starting CPAP treatment.