The effect of CPAP therapy on insulin-like growth factor and cognitive functions in obstructive sleep apnea patients

Kanbay A., Demir N. C. , TUTAR N. , Kostek O., Simsek Z. O. , Buyukoglan H., ...Daha Fazla

CLINICAL RESPIRATORY JOURNAL, cilt.11, sa.4, ss.506-513, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Konu: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/crj.12365
  • Sayfa Sayıları: ss.506-513


ObjectivesCognitive impairment is common among patients with obstructive sleep apnea syndrome (OSAS). In this study, we aimed to investigate the effect of continuous positive airway pressure (CPAP) therapy on serum insulin-like growth factor-1 (IGF-1) levels and cognitive functions in patients with OSAS.Patient/Methods: Thirty-three patients with newly diagnosed OSAS and 17 healthy-control subjects enrolled in the study. All individuals completed the mini-mental state examination (MMSE) to evaluate cognitive function. Blood samples were taken at the end of the polysomnography in the morning and the same procedures were repeated 3 months after starting CPAP treatment.