Nano-based drug delivery systems in hepatocellular carcinoma

Abtahi M. S., Fotouhi A., Rezaei N., AKALIN H., ÖZKUL Y., Hossein-Khannazer N., ...More

JOURNAL OF DRUG TARGETING, vol.32, no.9, pp.977-995, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 32 Issue: 9
  • Publication Date: 2024
  • Doi Number: 10.1080/1061186x.2024.2365937
  • Journal Name: JOURNAL OF DRUG TARGETING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, International Pharmaceutical Abstracts, MEDLINE
  • Page Numbers: pp.977-995
  • Keywords: Hepatocellular carcinoma (HCC), nano-drug delivery system, active targeting, niosomes, nanotechnology
  • Erciyes University Affiliated: Yes

Abstract

The high recurrence rate of hepatocellular carcinoma (HCC) and poor prognosis after medical treatment reflects the necessity to improve the current chemotherapy protocols, particularly drug delivery methods. Development of targeted and efficient drug delivery systems (DDSs), in all active, passive and stimuli-responsive forms for selective delivery of therapeutic drugs to the tumour site has been extended to improve efficacy and reduce the severe side effects. Recent advances in nanotechnology offer promising breakthroughs in the diagnosis, treatment and monitoring of cancer cells. In this review, the specific design of DDSs based on the different nano-particles and their surface engineering is discussed. In addition, the innovative clinical studies in which nano-based DDS was used in the treatment of HCC were highlighted.