Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ-induced kindling rat model


Taskiran M., Unal G.

EPILEPTIC DISORDERS, vol.23, no.6, pp.893-900, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.1684/epd.2021.1344
  • Journal Name: EPILEPTIC DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.893-900
  • Keywords: vortioxetine, SSRI, PTZ-induced epilepsy, seizure, NOR, DOUBLE-BLIND, FLUOXETINE, SEROTONIN, EPILEPSY, SEIZURES, SCHIZOPHRENIA, PLACEBO
  • Erciyes University Affiliated: Yes

Abstract

Objective. This study aimed to examine the effects of vortioxetine, a novel antidepressant, on epileptiform activity in pentylenetetrazole (PTZ)-induced kindling model in rats.