Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives

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Gürer-Orhan H., Orhan H., Süzen S., Puskullu M. O., Büyükbingöl E.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.21, sa.2, ss.241-247, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/14756360600586031
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.241-247
  • Anahtar Kelimeler: melatonin, benzimidazole, antioxidant activity, erythrocyte, in vitro, LIPID-PEROXIDATION, BIOLOGICAL-ACTIVITY, OXIDATIVE STRESS
  • Erciyes Üniversitesi Adresli: Hayır

Özet

New, except Id, melatonin analogue benzimidazole derivatives were synthesized and characterized in the present study. The potential role of melatonin as an antioxidant by scavenging and detoxifying ROS raised the possibility that compounds that are analogous to melatonin can also be used for their antioxidant properties. Therefore the antioxidant effects of the newly synthesized compounds were investigated in vitro by means of their inhibitory effect on hydrogen peroxide-induced erythrocyte membrane lipid peroxidation (EMLP) and on various erythrocyte antioxidant enzymes viz. superoxide dismutase (SOD), catalase (CAT) and glucose-6-phosphate dehydrogenase (G6PD). The synthesized benzimidazole derivatives showed remarkable antioxidant activity in vitro in the H2O2-induced EMLP system. Furthermore their effects on various antioxidant enzymes are discussed and evaluated from the perspective of structure-activity relationships.