Effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, steroid dependence, and small airways in patients with severe eosinophilic asthma


YILMAZ İ., Nazik Bahcecioglu S., Turk M., TUTAR N., PAÇACI ÇETİN G., ARSLAN B.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.4, pp.1953-1959, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2009-41
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1953-1959
  • Keywords: Mcpolizumab, severe cosinophilic asthma, small airways, pulmonary function, asthma control test, oral corticosteroids, EFFICACY, RHINOSINUSITIS, MULTICENTER, SAFETY
  • Erciyes University Affiliated: Yes

Abstract

Background: The efficacy of mepolizumab has been largely demonstrated in clinical trials in patients with severe eosinophilic asthma (SEA). However, reports on experience with mepolizumab in a real-life cohort are limited. Moreover, data about the effectiveness of mepolizumab on small airways is scarce. Objective: This study evaluated the effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, blood eosinophils, steroid dependence and small airways in a real-life cohort of patients with SEA.