Effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, steroid dependence, and small airways in patients with severe eosinophilic asthma

YILMAZ İ., Nazik Bahcecioglu S., Turk M., TUTAR N., PAÇACI ÇETİN G., ARSLAN B.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.4, ss.1953-1959, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2009-41
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1953-1959
  • Anahtar Kelimeler: Mcpolizumab, severe cosinophilic asthma, small airways, pulmonary function, asthma control test, oral corticosteroids, EFFICACY, RHINOSINUSITIS, MULTICENTER, SAFETY
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background: The efficacy of mepolizumab has been largely demonstrated in clinical trials in patients with severe eosinophilic asthma (SEA). However, reports on experience with mepolizumab in a real-life cohort are limited. Moreover, data about the effectiveness of mepolizumab on small airways is scarce. Objective: This study evaluated the effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, blood eosinophils, steroid dependence and small airways in a real-life cohort of patients with SEA.