Effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, steroid dependence, and small airways in patients with severe eosinophilic asthma


YILMAZ İ. , Nazik Bahcecioglu S., Turk M., TUTAR N. , PAÇACI ÇETİN G. , ARSLAN B.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.4, pp.1953-1959, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2009-41
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.1953-1959
  • Keywords: Mcpolizumab, severe cosinophilic asthma, small airways, pulmonary function, asthma control test, oral corticosteroids, EFFICACY, RHINOSINUSITIS, MULTICENTER, SAFETY

Abstract

Background: The efficacy of mepolizumab has been largely demonstrated in clinical trials in patients with severe eosinophilic asthma (SEA). However, reports on experience with mepolizumab in a real-life cohort are limited. Moreover, data about the effectiveness of mepolizumab on small airways is scarce. Objective: This study evaluated the effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, blood eosinophils, steroid dependence and small airways in a real-life cohort of patients with SEA.