In the title compound, C(23)H(21)NO(3)S, the piperidine ring of the tetrahydroisoquinolinone unit adopts a screw-boat conformation. The thiophene ring is disordered in a 0.700 (3): 0.300 (3) ratio by an approximate 180 degrees rotation of the ring around the C-C bond linking the ring to the tetrahydroisoquinolinone unit. The benzene ring of the tetrahydroisoquinolinone unit makes dihedral angles of 83.1 (2) and 62.38 (11)degrees with the major occupancy thiophene ring and the phenyl ring, respectively. The dihedral angle between the phenyl ring and the thiophene ring is 71.0 (2)degrees. In the crystal structure, molecules are linked together by intermolecular C-H center dot center dot center dot O and C-H center dot center dot center dot pi interactions.