Sister chromatid exchange frequency in inhabitants exposed to asbestos in Turkey


Donmez H. , Ozkul Y. , Ucak R.

MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS, vol.361, pp.129-132, 1996 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 361
  • Publication Date: 1996
  • Doi Number: 10.1016/s0165-1161(96)90247-2
  • Title of Journal : MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS
  • Page Numbers: pp.129-132
  • Keywords: sister chromatid exchange, asbestos, human lymphocyte, CHROMOSOMAL-ABERRATIONS, LYMPHOCYTE CHROMOSOMES, CROCIDOLITE, CHRYSOTILE, INVITRO, WORKERS

Abstract

Pleural mesothelioma, lung cancer, pleural calcification and fibrosis have been observed among inhabitants of the villages in Ivriz-Zanapa valley in Turkey. Earlier reports have stated that these endemic pathological conditions are caused by the inhalation of actinolite asbestos, a mineral commonly used indiscriminately to paint the walls and floors of houses. In the present study, 40 inhabitants in Yassikaya village in Ivriz-Zanapa valley and 20 controls were further investigated. The peripheral blood lymphocytes were cultured and harvested at 72 h for sister chromatid exchange (SCE) frequency. Inhabitants had a raised mean SCE rate compared with a control population.