INTERNATIONAL CONFERENCE ON APPLICATION IN CEHMISTRY AND CHEMICAL ENGINEERING (ICACCHE), Skopje, Makedonya, 11 - 15 Eylül 2019, ss.2
Pyrazolo[1,5-c]pyrimidines are biologically active, synthetically useful and important heterocyclic compounds. The synthesis of novel pyrazolo-pyrimidine derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades for biological, medicinal and agricultural reasons. Different classes of pyrazolo-pyrimidine compounds possess an extensive spectrum of pharmacological activities. Differently substituted pyrazolo[1,5-c]pyrimidine moiety has also been found to have other important activities such as antibacterial, antifungal, anti-inflammatory, antifungal, anticonvulsant, analgesic, antimicrobial, antitumor, cytotoxic and herbicidal [1,2].
It should be noted that pyrazolo[1,5-c]pyrimidines are least studied among various types of pyrazolo-pyrimidines. Due to our interest in pyrazolo[1,5-c]pyrimidines, we have investigated the reactivity and synthetic applications of these compounds. Herein, we report the first synthesis of pyrazolo[1,5-c] pyrimidines by reactions of 1-amino-5-(aroyl)-4-(aryl)pyrimidin-2(1H)-one and its pyrimidine-2(1H)-thione are synthesized in two steps from 4-(aroyl)-5-(aryl)furan-2,3-dione [2-4] using DMAD, DEAD, ethyl-2-chloroacetoacetate, 3-chloroacetylacetone as electrophiles. The result of these experiments is discussed in this study. The chemical structure of synthesized derivatives will be elucidated by elementary analysis, FT-IR and NMR spectroscopic techniques after the pureness control of them done by TLC and melting point analyses.