CONTRACEPTIVE STEROIDS INCREASE ERYTHROCYTE LIPID-PEROXIDATION IN FEMALE RATS


KOSE K. , DOGAN P. , OZESMI C.

CONTRACEPTION, vol.47, no.4, pp.421-425, 1993 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 4
  • Publication Date: 1993
  • Doi Number: 10.1016/0010-7824(93)90039-a
  • Title of Journal : CONTRACEPTION
  • Page Numbers: pp.421-425

Abstract

In order to investigate the effects of contraceptive steroid combinations on lipid peroxidation in the erythrocyte membranes, adult female rats were divided into 2 groups for short- and long-term investigations; each group was then subdivided into 5 subgroups according to orally given low and high doses of EE/NEA (ethinyl estradiol/norethisterone acetate) and EE/LNG (ethinyl estradiol/levonorgestrel) combinations and control group. Since EE was included in each combination, the groups were named according to the progestin (NEA, LNG) components. At the end of the experiment periods, lipid peroxidation in the erythrocyte membranes from rats was measured.