REVUE DE MEDECINE VETERINAIRE, cilt.159, ss.332-337, 2008 (SCI İndekslerine Giren Dergi)
This report describes the case of a bilateral RCC (renal cell carcinoma) with unusual thyroid metastases in a 9 year-old male Anatolian Karabash dog with a history of lethargy, anorexia, depression, dyspnoea and snoring. At necropsy, external and internal solitary masses were found in the left and right kidneys respectively and tumoral nodules were detected in the left adrenal gland, in the regional lymphatic nodes. in lungs and also in the totally necrotic left and right thyroid glands. Histologically, the neoplastic tissues showed solid and tubular cellular structures typical of carcinoma. The RCC diagnosis was confirmed by the double vimentin (V9) and cytokeratin (AE1/AE3) immuno-labelling in the primary renal tumours as well as in the secondary tumours. This is the first report showing thyroid metastases from RCC in the dog.