Pharmacokinetics and bioequivalence study of doxycycline capsules in healthy male subjects


Gschwend M. H. , Martin W., Erenmemisoglu A. , Scherm M., Dilger C., Tamur U., ...More

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.57, no.6, pp.347-351, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 6
  • Publication Date: 2007
  • Title of Journal : ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Page Numbers: pp.347-351

Abstract

The aim of the present study was to compare the bioavailability of doxycycline (CAS 564-25-0) from two different doxycycline hyclate (CAS 24390-14-5) capsules (Monodoks((R)) 100 mg capsule as test preparation and 100 mg capsule of the originator product as reference preparation) in 24 healthy male subjects. The study was conducted according to an open-label, randomised two-period cross-over design with a wash-out phase of 16 days. Blood samples for pharmacokinetic profiling were taken up to 72 h post-dose, and doxycycline plasma concentrations were determined with a validated HPLC method with UV-detection.