Functionalization Reactions of Various Pyrazole-3-carboxylic Acid Chlorides with Some Ureas


Creative Commons License

İLHAN I. Ö. , Demirkol K., Onal Z. , AKKOÇ S. , ÇADIR M.

ASIAN JOURNAL OF CHEMISTRY, cilt.26, ss.2365-2368, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 26 Konu: 8
  • Basım Tarihi: 2014
  • Doi Numarası: 10.14233/ajchem.2014.16000
  • Dergi Adı: ASIAN JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.2365-2368

Özet

The 1H-pyrazole-3-carboxylic acids 2 or their remarkably stable acid chlorides 3 can easily be converted into the corresponding 1H-pyrazole-3-carbonyl-N'-urea derivatives (5a-k) from reaction with urea nucleophiles. It has been demonstrated that with the variation in reaction conditions, the reaction changes thus leading to different products. All newly synthesized compounds were characterized by elemental analysis, FT-IR, H-1 and C-13 NMR spectral data. All compounds were compared with their previous analogues.
Abstract

The 1H-pyrazole-3-carboxylic acids 2 or their remarkably stable acid chlorides 3 can easily be converted into the corresponding 1H-pyrazole-3-carbonyl-N'-urea derivatives (5a-k) from reaction with urea nucleophiles. It has been demonstrated that with the variation in reaction conditions, the reaction changes thus leading to different products. All newly synthesized compounds were characterized by elemental analysis, FT-IR, H-1 and C-13 NMR spectral data. All compounds were compared with their previous analogues.