Functionalization Reactions of Various Pyrazole-3-carboxylic Acid Chlorides with Some Ureas


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İLHAN I. Ö. , Demirkol K., Onal Z. , AKKOÇ S. , ÇADIR M.

ASIAN JOURNAL OF CHEMISTRY, vol.26, no.8, pp.2365-2368, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 8
  • Publication Date: 2014
  • Doi Number: 10.14233/ajchem.2014.16000
  • Title of Journal : ASIAN JOURNAL OF CHEMISTRY
  • Page Numbers: pp.2365-2368

Abstract

Abstract

The 1H-pyrazole-3-carboxylic acids 2 or their remarkably stable acid chlorides 3 can easily be converted into the corresponding 1H-pyrazole-3-carbonyl-N'-urea derivatives (5a-k) from reaction with urea nucleophiles. It has been demonstrated that with the variation in reaction conditions, the reaction changes thus leading to different products. All newly synthesized compounds were characterized by elemental analysis, FT-IR, H-1 and C-13 NMR spectral data. All compounds were compared with their previous analogues.

The 1H-pyrazole-3-carboxylic acids 2 or their remarkably stable acid chlorides 3 can easily be converted into the corresponding 1H-pyrazole-3-carbonyl-N'-urea derivatives (5a-k) from reaction with urea nucleophiles. It has been demonstrated that with the variation in reaction conditions, the reaction changes thus leading to different products. All newly synthesized compounds were characterized by elemental analysis, FT-IR, H-1 and C-13 NMR spectral data. All compounds were compared with their previous analogues.