Experimental posterior perforating ocular injury in rabbit eyes: Effects of radiotherapy with or without intravitreal cyclosporin on vitreous proliferation

KARAKUCUK S., SOYUER S., Oner A., Soyuer I., Yaray K., Mirza E., ...Daha Fazla

OPHTHALMOLOGICA, cilt.220, sa.1, ss.6-11, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 220 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1159/000089268
  • Dergi Adı: OPHTHALMOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6-11
  • Anahtar Kelimeler: radiotherapy, eye injuries, rabbits, cyclosporin, proliferative vitreoretinopathy, EXPERIMENTAL INTRAOCULAR PROLIFERATION, LOCALIZED GAMMA-IRRADIATION, HIGH-ENERGY ELECTRONS, RETINAL TOXICITY, UVEITIS, RELEASE, SEGMENT
  • Erciyes Üniversitesi Adresli: Evet

Özet

Double perforating ocular injuries were made in 30 rabbits and the effects of radiotherapy (RT) alone or in combination with cyclosporin (CS) on vitreous proliferation investigated. Thirteen rabbits in group 1 received RT alone (600 cGy), and 13 rabbits in group 2 received RT combined with 100 mu g of intravitreal CS. No treatment was given to 4 rabbits in the control group ( group 3). All animals were ophthalmologically examined on the 1st, 3rd, 7th, 14th and 28th days following the injury and the clinical findings scored; they were sacrificed on the 28th day, and histopathological scoring was made. The median histopathological score of the RT group (4.0; range: 0-8) was significantly higher than that of the CS + RT group (1.0; range: 0-5; p = 0.018). We conclude that intravitreal CS may be used as an adjunctive agent to RT to inhibit intraocular proliferation following penetrating ocular injury in rabbits. Copyright (c) 2006 S. Karger AG, Basel.