Two new eudesmane-type sesquiterpene derivatives from Lecokia cretica (Lam.) DC.

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TABAN AKÇA K., GÜRBÜZ P., DOĞAN Ş. D., EMERCE E., Gören A. C., Polat R., ...More

Natural product research, vol.38, no.9, pp.1494-1502, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 9
  • Publication Date: 2024
  • Doi Number: 10.1080/14786419.2022.2153301
  • Journal Name: Natural product research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1494-1502
  • Keywords: Lecokia cretica, Apiaceae, eudesmane, sesquiterpene, cell viability, cytotoxic activity
  • Erciyes University Affiliated: Yes

Abstract

© 2022 Informa UK Limited, trading as Taylor & Francis Group.Two new sesquiterpene glucosides, 1α,6β,9β-trihydroxy-eudesm-4(15)-en-1,6-O-β-diglucopyranoside (1) and 1α,6β,9β-trihydroxy-eudesm-3-en-1,6-O-β-diglucopyranoside (2) were obtained along with the 1α,6β,9β-trihydroxy-5,10-bis-epi-eudesm-3-en-6-O-β-D-glucopyranoside (3), chlorogenic acid (4), luteolin 7-O-rutinoside (5) and luteolin 7-O- glucoside (6) from the whole plant parts of Lecokia cretica. Their structures were determined on the basis of 1 D, 2 D NMR and HRMS analyses. The in vitro cytotoxic activity of compounds 1-3 against human lung cancer cells (A549) and normal human lung cells (BEAS-2B) was determined using the MTT colorimetric assay. All the tested eudesmane derivatives were found to be inactive.