Akademik Veri Yönetim Sistemi
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, cilt.13, sa.10, ss.1153-1157, 2022 (ESCI)
Aim: The aim of this study was to compare the circulatory inflammatory cells in peripheral blood tests of patients with odontogenic cysts and healthy subjects and the effect of these markers between the development and enlargement of cysts. Material and Methods: Ninety-eight patients with an odontogenic cyst in the maxillofacial region (Group 1) and 102 healthy subjects as control (Group 2) were included in the study. White blood cell count, neutrophil count, lymphocyte count, platelet count, neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet to lymphocyte ratio (PLR) were compared between groups. In addition, the correlation of these markers with volume of the cysts was determined. Results: Fifty-six radicular cysts, 34 dentigerous cysts, and 8 odontogenic keratocysts were observed in Group 1. Lymphocyte count, platelet count, and MPV were statistically higher in Group 2 (p < 0.05). The optimum cut-off level for MPV was detected as 8.7 according to the ROC analysis (Sensitivity: 85, Specificity: 80). The median cyst volume was 4663 mm3 (min: 1213 max: 48553) and cyst volume was not different according to the type of the cyst (p=0.063). A positive and significant correlation between neutrophil count and PLR with cyst volume was observed (p=0.023, p=0.007) Discussion: This study considered the effect of circulatory inflammatory cells on the pathogenesis of jaw cysts. Lower platelet counts and MPV may have an essential role in the development of cystic jaw lesions and higher circulating neutrophils may be associated with an expansion of the cysts.