Pyrazinamide-Induced Anaphylaxis: Diagnosed by Skin Test and Successful Desensitization

Bavbek S., Yilmaz I., Aydin O., Ozdemir S. K.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, vol.157, no.2, pp.209-212, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 157 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1159/000327537
  • Journal Name: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.209-212
  • Keywords: Anaphylaxis, Pyrazinamide, Prick test, Desensitization, GENERAL-CONSIDERATIONS, PATIENT
  • Erciyes University Affiliated: Yes

Abstract

Pyrazinamide (PZA), an antituberculosis drug, may cause hypersensitivity reactions. Here, we report a case of anaphylaxis secondary to a PZA administration for tuberculosis pleuritis. To the best of our knowledge, this is the first reported case of strongly possible IgE-mediated, PZA-induced anaphylaxis proved by skin prick test and oral provocation/desensitization. Copyright (C) 2011 S. Karger AG, Basel