Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity

TAŞKIRAN M., Tasdemir A., AYYILDIZ N.

BRAIN RESEARCH BULLETIN, cilt.130, ss.42-46, 2017 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 130
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.brainresbull.2016.12.010
  • Dergi Adı: BRAIN RESEARCH BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.42-46
  • Anahtar Kelimeler: Aceclofenac, COX-2 inhibitor, Proconvulsant, Epileptiform activity, Acute, ACID-INDUCED SEIZURE, CYCLOOXYGENASE-2 EXPRESSION, POSSIBLE MECHANISM, PILOCARPINE MODEL, ANIMAL-MODELS, EPILEPSY, INVOLVEMENT, CONVULSIONS, ETORICOXIB, METABOLISM
  • Erciyes Üniversitesi Adresli: Evet

Özet

Purpose: The effects of COX-2 inhibitors on seizure activity are controversial. The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy.