Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity


TAŞKIRAN M., Tasdemir A., AYYILDIZ N.

BRAIN RESEARCH BULLETIN, vol.130, pp.42-46, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 130
  • Publication Date: 2017
  • Doi Number: 10.1016/j.brainresbull.2016.12.010
  • Journal Name: BRAIN RESEARCH BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.42-46
  • Keywords: Aceclofenac, COX-2 inhibitor, Proconvulsant, Epileptiform activity, Acute, ACID-INDUCED SEIZURE, CYCLOOXYGENASE-2 EXPRESSION, POSSIBLE MECHANISM, PILOCARPINE MODEL, ANIMAL-MODELS, EPILEPSY, INVOLVEMENT, CONVULSIONS, ETORICOXIB, METABOLISM
  • Erciyes University Affiliated: Yes

Abstract

Purpose: The effects of COX-2 inhibitors on seizure activity are controversial. The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy.