Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

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Regassa A., Rings F., Hoelker M., Cinar U., Tholen E., Looft C., ...More

BMC GENOMICS, vol.12, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2011
  • Doi Number: 10.1186/1471-2164-12-57
  • Journal Name: BMC GENOMICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Erciyes University Affiliated: No

Abstract

Background: The bi-directional communication between the oocyte and its companion cumulus cells (CCs) is crucial for development and functions of both cell types. Transcripts that are exclusively expressed either in oocytes or CCs and molecular mechanisms affected due to removal of the communication axis between the two cell types is not investigated at a larger scale. The main objectives of this study were: 1. To identify transcripts exclusively expressed either in oocyte or CCs and 2. To identify those which are differentially expressed when the oocyte is cultured with or without its companion CCs and vice versa.