Adipose-Derived Stem Cells Enhance Axonal Regeneration through Cross-Facial Nerve Grafting in a Rat Model of Facial Paralysis
PLASTIC AND RECONSTRUCTIVE SURGERY, vol.138, no.2, pp.387-396, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 138 Issue: 2
- Publication Date: 2016
- Doi Number: 10.1097/prs.0000000000002351
- Journal Name: PLASTIC AND RECONSTRUCTIVE SURGERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.387-396
- Erciyes University Affiliated: Yes
Abstract
Background: Cross-face nerve grafting combined with functional muscle transplantation has become the standard in reconstructing an emotionally controlled smile in complete irreversible facial palsy. However, the efficacy of this procedure depends on the ability of regenerating axons to breach two nerve coaptations and reinnervate endplates in denervated muscle. The current study tested the hypothesis that adipose-derived stem cells would enhance axonal regeneration through a cross-facial nerve graft and thereby enhance recovery of the facial nerve function.