Adipose-Derived Stem Cells Enhance Axonal Regeneration through Cross-Facial Nerve Grafting in a Rat Model of Facial Paralysis


ABBAS O. L., BORMAN H., UYSAL A. Ç., GÖNEN Z. B., AYDIN L., HELVACIOĞLU F., ...More

PLASTIC AND RECONSTRUCTIVE SURGERY, vol.138, no.2, pp.387-396, 2016 (SCI-Expanded) identifier identifier identifier

Abstract

Background: Cross-face nerve grafting combined with functional muscle transplantation has become the standard in reconstructing an emotionally controlled smile in complete irreversible facial palsy. However, the efficacy of this procedure depends on the ability of regenerating axons to breach two nerve coaptations and reinnervate endplates in denervated muscle. The current study tested the hypothesis that adipose-derived stem cells would enhance axonal regeneration through a cross-facial nerve graft and thereby enhance recovery of the facial nerve function.