Reversible posterior leukoencephalopathy syndrome in childhood: report of nine cases and review of the literature

Gumus H., PER H., KUMANDAŞ S., Yikilmaz A.

NEUROLOGICAL SCIENCES, cilt.31, sa.2, ss.125-131, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s10072-009-0158-z
  • Dergi Adı: NEUROLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.125-131
  • Anahtar Kelimeler: Reversible posterior leukoencephalopathy syndrome, Childhood, Granulocyte-colony stimulating factor, ENCEPHALOPATHY SYNDROME, HYPERTENSIVE ENCEPHALOPATHY, POSTSTREPTOCOCCAL GLOMERULONEPHRITIS, MR-ANGIOGRAPHY, ECLAMPSIA, SEIZURES, UTILITY, ERYTHROPOIETIN, PREECLAMPSIA, CHILDREN
  • Erciyes Üniversitesi Adresli: Evet

Özet

Reversible posterior leukoencephalopathy syndrome (RPLS) is recently described disorder with typical radiological findings in the posterior regions of the cerebral hemisphere and cerebellum. Its clinical symptoms include headache, decreased alertness, mental abnormalities, such as confusion, diminished spontaneity of speech, and changed behavior ranging from drowsiness to stupor, seizures, vomiting and abnormalities of visual perception like cortical blindness. RPLS is caused by various heterogeneous factors, the commonest being hypertension, followed by non-hypertensive causes such as eclampsia, renal diseases and immunosuppressive therapy. We presented nine patients with RPLS who had primary diagnoses such as acute post-streptococcal glomerulonephritis, idiopathic hypertension, the performing of intravenous immunoglobulin for infection with crescentic glomerulonephritis, erythrocyte transfusion for severe iron deficiency, l-asparaginase treatment for acute lymphoblastic leukemia and performing of granulocyte-colony stimulating factor for ulcerative colitis due to neutropenia. Early recognition of RPLS as complication during different diseases and therapy in childhood may facilitate precise diagnosis and appropriate treatment.