Suberoylanilide hydroxamic acid inhibits LX2 cells proliferation via decreasing yes-associated protein/transcriptional coactivator with PDZ-binding motif proteins

Ozel M., Guclu K., KILIÇ E., BAŞKOL M., BAŞKOL G., Helvaci N.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.46, sa.3, ss.299-305, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1515/tjb-2019-0397
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.299-305
  • Anahtar Kelimeler: hepatic fibrosis, hippo pathway, suberoylanilide hydroxamic acid, YAP/TAZ, HISTONE DEACETYLASES, LIVER FIBROSIS, YAP, CANCER
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background: Hepatic fibrosis is a complex and dynamic process similar to "wound healing" that results in the progressive accumulation of connective tissue. We aimed to investigate the epigenetic control of liver fibrosis and Hippo pathway in human hepatic stellate cell (HSC) line. We examined the effect of Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor on the LX2 cell line.