Polymeric complex based on poly (styrene-alt-maleic anhydride)- targeted with folic acid for doxorubicin delivery to HT-29 colorectal cancer cells


Molaparast M., Ehsanimehr S., Kahyaei M., Mahboubi N., Shafiei-Irannejad V.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.1080/00914037.2021.1999953
  • Title of Journal : INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Keywords: Anti-cancer, cyclodextrin, drug-polymer complex, folic acid, targeted drug delivery, COMBINATION CHEMOTHERAPY, NANO-VEHICLE, NANOPARTICLES, CHITOSAN, SMART

Abstract

In this study, a drug-polymer complex for targeted delivery of doxorubicin to cancer cells based on poly (styrene-alt-maleic-anhydride) copolymer was synthesized. The targeted polymer complex has shown a greater effect on cell growth than pure drugs. Targeted polymer complex containing doxorubicin which is targeted by folic acid receptors, was shown to increase the effects of the drug on HT-29 colorectal cancer cells, which have a high concentration of folate receptors on its cell wall. Based on these results, this drug-carrying system may be valuable in reducing the dose of doxorubicin its systemic side effects.