Purpose: We aimed the investigate of the effect of iv paracetamol on hemodynamic indices, liver functions in the patients underwent major orthopaedic surgery. Material and Methods: This study was performed on 120 patients with ASA I-II risk group underwent major ortopaedic surgery. The patients are randomly divided into there groups: Group I (only iv meperidine), Group II (Parasetamol in doses 1g is intravenously given by infusion during the 30 mins ago end of the operation, and this dose is repeated in every 6 hours.) and Group III: Parasetamol iv 1gr is given by infusion during the 30 mins ago from the anesthesia induction, and this dose is repeated in every 6 hours. Patient Control Anaestesia (PCA) method; meperidin was administered via PCA as loading dose 0.5mg/kg, set bolus dose 0.1mg/kg and standing locked term 10 mins. Blood for ALT and AST taken on preoperative and postoperative 24th hour is examined. Results: In control group, compared with parasetamol and preemptive groups, SAP in postop 60th, DAP in postop 30. and 60th mins, HR in postop 15th mins were recorded higher. The preop and postop examined ALT and AST were similar. Conclusion: We concluded that iv paracetamol administration to the patients underwent to major ortopaedic surgery did not cause negative hemodynamic results and liver functions.