SAHA modulates cell proliferation, colony forming and epithelial-mesenchymal transition in CCA cells

BAŞKOL G., ÖZEL M., Ucar C., Dogru B. N., Yuksek E. H., Gunes F., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.44, sa.1, ss.70-77, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1515/tjb-2018-0029
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.70-77
  • Anahtar Kelimeler: Cholangiocarcinoma, Suberoylanilide hydroxamic acid, Epithelial-mesenchymal transition, Epigenetic, E-cadherin, PREDICTS PROGNOSIS, CHOLANGIOCARCINOMA, PROMOTES, MIGRATION, THERAPY, MARKER
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background: Therapeutic options for advanced cholangiocarcinoma (CCA) are limited and ineffective due to the largely incomplete understanding of the molecular pathogenesis of this deadly tumor. So that, we planned to investigate epigenetic regulation of epithelial-mesenchymal transition (EMT) in cholangiocarcinoma cell line by applying Suberoylanilide hydroxamic acid (SAHA). We studied the effect of SAHA on cell proliferation, colony forming, migration and protein level of E-cadherin (E-cad) as an epithelial EMT marker, N-cadherin (N-cad) and Vimentin (Vim), as a mesenchymal markers of EMT, in human CCA cell line.