Renal tubular dysgenesis with atypical histology and in-utero exposure to naproxen sodium


Koklu E., GURGOZE M., Akgun H., Ozturk M. A., POYRAZOGLU M. H.

ANNALS OF TROPICAL PAEDIATRICS, vol.26, no.3, pp.241-245, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1179/146532806x120345
  • Journal Name: ANNALS OF TROPICAL PAEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.241-245
  • Erciyes University Affiliated: Yes

Abstract

Renal tubular dysgenesis (RTD), a rare, lethal, autosomal recessive disorder, is characterised by short and poorly differentiated proximal convoluted tubules associated with oligohydramnios, Potter sequence and neonatal death from respiratory failure. We report an unusual case of neonatal anuria owing to RTD with normally formed lungs, in-utero exposure to naproxen sodium and atypical histology in that the glomeruli were not as crowded as usually seen in RTD. When there is anuria in an infant following birth in the context of a normal renal ultrasound and an absence of objective evidence of perinatal hypoxia, RTD should be considered.