Assessment of DNA damage and plasma catalase activity in healthy term hyperbilirubinemic infants receiving phototherapy
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, cilt.680, ss.12-16, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 680
- Basım Tarihi: 2009
- Doi Numarası: 10.1016/j.mrgentox.2009.07.016
- Dergi Adı: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.12-16
- Anahtar Kelimeler: DNA damage, Hyperbilirubinemia, Phototheraphy, Comet assay, COMET ASSAY, NEONATAL HYPERBILIRUBINEMIA, OXIDATIVE STRESS, FOLLOW-UP, IN-VITRO, BILIRUBIN, ANTIOXIDANT, PRETERM, MECHANISM, ABSENCE
- Erciyes Üniversitesi Adresli: Evet
Özet
Phototherapy (PT) is the most widely used form of treatment for unconjugated hyperbilirubinemia. One possible harmful consequence of PT is of a genetic nature. High levels of bilirubin may lead to oxidative damage in newborns: photochemical reactions may produce toxic photoproducts, probably peroxides. In order to investigate this hypothesis further under in vivo conditions, DNA strand-break frequency was examined by means of the comet assay in peripheral lymphocytes of icteric newborns undergoing PT treatment, and the levels of catalase, an antioxidant enzyme, were determined.