Single dose of anti-transforming growth factor-beta(1) monoclonal antibody enhances liver regeneration after partial hepatectomy in biliary-obstructed rats


Deneme M. A. , Ok E. , AKCAN A., AKYILDIZ H., Soyuer I. , Muhtaroglu S.

JOURNAL OF SURGICAL RESEARCH, cilt.136, ss.280-287, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 136 Konu: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jss.2006.08.020
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayıları: ss.280-287

Özet

Background. Transforming growth factor (TGF) beta is a potent inhibitor of hepatocyte DNA synthesis and liver regeneration. TGF-beta(1) expression progressively increases in obstructive jaundice. We investigated the effect of TGF-beta(1) blockage on liver regeneration in rats induced with obstructive jaundice.