Single dose of anti-transforming growth factor-beta(1) monoclonal antibody enhances liver regeneration after partial hepatectomy in biliary-obstructed rats

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Deneme M. A., Ok E., AKCAN A., AKYILDIZ H. Y., Soyuer I., Muhtaroglu S.

JOURNAL OF SURGICAL RESEARCH, vol.136, no.2, pp.280-287, 2006 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 136 Issue: 2
• Publication Date: 2006
• Doi Number: 10.1016/j.jss.2006.08.020
• Journal Name: JOURNAL OF SURGICAL RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.280-287
• Keywords: TGF-beta(1), liver regeneration, obstructive jaundice, partial hepatectomy, FACTOR-BETA, DNA-SYNTHESIS, CELL-PROLIFERATION, ENDOTHELIAL GROWTH, MESSENGER-RNA, II RECEPTOR, PORTAL-VEIN, BILE-DUCT, HEPATOCYTES, EXPRESSION
• Erciyes University Affiliated: Yes

Abstract

Background. Transforming growth factor (TGF) beta is a potent inhibitor of hepatocyte DNA synthesis and liver regeneration. TGF-beta(1) expression progressively increases in obstructive jaundice. We investigated the effect of TGF-beta(1) blockage on liver regeneration in rats induced with obstructive jaundice.