Akademik Veri Yönetim Sistemi
V. INTERNATIONAL ICONTECH CONFERENCE ON INNOVATIVE SURVEYS IN POSITIVE SCIENCES, Şanlıurfa, Türkiye, 5 - 06 Şubat 2022, ss.66-72
Autistic Spectrum Disorder (ASD) is a disorder characterized by observing abnormal behavior, criteria
focusing on impaired social communication and interaction, and restricted, repetitive patterns of
behavior, interests, or activities. Although its etiology is very complex, it is known that genetic and
environmental factors play a role. Although the prevalence of ASD has increased steadily in the last
two decades, the pathophysiological and genetic mechanisms underlying autism are not yet fully
understood, and the unknowns are the most important factors affecting and complicating the treatment
of the disease. The Alpha Synuclein gene (SNCA) is located on human chromosome 4 and encodes the
alpha-synuclein protein. Alpha-synuclein is a protein highly expressed at brain presynaptic terminals,
but its function is not well known. Some studies have shown that alpha-synuclein plays a key role in
the regulation of neurotransmitter release, synaptic function and plasticity of dopaminergic neurons. It
has been suggested that alpha-synuclein can modulate gene expression by interacting with histones,
nuclear proteins such as transcription factors, and various promoters in the cell nucleus. The effect of
alpha-synuclein (SNCA) gene and protein level on autism and its biological role in this disease have
not been fully elucidated yet. The aim of this study is to determine the serum alpha-synuclein level in
patients with autism and to reveal whether there is an expression difference compared to healthy
controls.