RELATIONSHIP BETWEEN AUTISM AND ALPHA-SYNUCLEIN


Badıllı M., Tahtasakal R., Pirenci Ş. N., Şahin M., Tuğhan E., Dal F., ...More

V. INTERNATIONAL ICONTECH CONFERENCE ON INNOVATIVE SURVEYS IN POSITIVE SCIENCES, Şanlıurfa, Turkey, 5 - 06 February 2022, pp.66-72

  • Publication Type: Conference Paper / Full Text
  • City: Şanlıurfa
  • Country: Turkey
  • Page Numbers: pp.66-72
  • Erciyes University Affiliated: Yes

Abstract

Autistic Spectrum Disorder (ASD) is a disorder characterized by observing abnormal behavior, criteria

focusing on impaired social communication and interaction, and restricted, repetitive patterns of

behavior, interests, or activities. Although its etiology is very complex, it is known that genetic and

environmental factors play a role. Although the prevalence of ASD has increased steadily in the last

two decades, the pathophysiological and genetic mechanisms underlying autism are not yet fully

understood, and the unknowns are the most important factors affecting and complicating the treatment

of the disease. The Alpha Synuclein gene (SNCA) is located on human chromosome 4 and encodes the

alpha-synuclein protein. Alpha-synuclein is a protein highly expressed at brain presynaptic terminals,

but its function is not well known. Some studies have shown that alpha-synuclein plays a key role in

the regulation of neurotransmitter release, synaptic function and plasticity of dopaminergic neurons. It

has been suggested that alpha-synuclein can modulate gene expression by interacting with histones,

nuclear proteins such as transcription factors, and various promoters in the cell nucleus. The effect of

alpha-synuclein (SNCA) gene and protein level on autism and its biological role in this disease have

not been fully elucidated yet. The aim of this study is to determine the serum alpha-synuclein level in

patients with autism and to reveal whether there is an expression difference compared to healthy

controls.