Distribution and concentration of Se, Mn, Fe, Co, Cu, Ni, Zn, Cd, Pb and Cr were determined in different depths of soil collected from industrial and agricultural lands in Kayseri (Turkey) using ICP-OES methods. The possibility of industrial and agricultural pollution by these elements in soil core was investigated using combined enrichment and anthropogenic factor formulas. The concentration of selenium and other trace elements in the surface soil was higher than in subsoil and deep subsoil. The results showed that concentrations of Co, Cr, Ni and Pb decreased with soil depth, but Mn steadily increased with depth. The maximum value of enrichment factor (EF) was obtained from nickel, and that of anthropogenic factor (AF) from cadmium, in depths of 35-50 cm.