Investigating the mRNA expression of IL-8 in Response to Lipopolysaccharide (LPS) and Lipoteichoic Acid (LTA) Stimulation in Sheep Alveolar Macrophages

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Sohel M. M. H. , Çinar M. U.

11th INTERNATIONAL ANIMAL SCIENCE CONGRESS, Kayseri, Turkey, 20 - 22 October 2019, pp.79-80

  • Publication Type: Conference Paper / Full Text
  • City: Kayseri
  • Country: Turkey
  • Page Numbers: pp.79-80


The immune system of an organism is the most important defense system against harmful pathogens and this system is tightly regulated by the timely expression of several genes. Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. It has a distinct target specificity for the neutrophil cells. IL-8 attracts and activates neutrophils in inflammatory regions. The aim of present study was to investigate the dynamics of expression of IL-8 in response to LPS and LTA in different time points which could later be used to select sheep against respiratory diseases effectively (Janette and Etheresia, 2016)