Akademik Veri Yönetim Sistemi
Electrochimica Acta, cilt.538, 2025 (SCI-Expanded, Scopus)
A new electrochemical sensing platform was fabricated in this work, utilizing a novel electrode modification strategy to enhance analytical performance. An innovative electrochemical sensor was constructed by modifying the electrode surface with a graphene oxide–calcium molybdenum layered double hydroxide (GO@CaMo-LDH) nanocomposite. This sensor demonstrated high sensitivity and selectivity for quantifying Binimetinib (BINI) in both pharmaceutical formulations and biological matrices. Differential pulse voltammetry (DPV) measurements revealed a linear response over a wide concentration range of 0.15 to 5.6 μM (R² = 0.997), with a detection limit (LOD) of 8.6 nM and a limit of quantification (LOQ) of 28.9 nM. The developed electrode demonstrated robust anti-interference capability, as the presence of common interfering species did not significantly affect the oxidation signal of BINI. Furthermore, the sensor displayed excellent repeatability (RSD = 1.05 %) and reproducibility (RSD = 1.34 %) across independently fabricated electrodes. The practical utility of the proposed sensor was confirmed by successful recovery results (96–102 %) in pharmaceutical formulations, as well as in human urine and human serum samples, emphasizing its applicability for real-sample analysis. The method's greenness and sustainability were systematically evaluated using the Green Analytical Procedure Index (GAPI), Analytical Greenness Metric (AGREE), and Blue Applicability Grade Index (BAGI), all indicating a high level of environmental and practical suitability. The GO@CaMo-LDH/GCE demonstrated outstanding performance in electrochemical analysis, highlighting its potential as a reliable platform for routine monitoring of BINI in clinical diagnostics and pharmaceutical quality control applications.