The chondrotoxic and apoptotic effects of levobupivacaine and bupivacaine on the rabbit knee joint

Cevik O., Gergın O. O., Yıldız K., Bayram A., Canöz Ö., Halıcı M., ...More

REVISTA BRASILEIRA DE ANESTESIOLOGIA, vol.68, pp.605-612, 2018 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68
  • Publication Date: 2018
  • Doi Number: 10.1016/j.bjan.2018.06.013
  • Journal Name: REVISTA BRASILEIRA DE ANESTESIOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.605-612
  • Keywords: Apoptosis, Bupivacaine, Chondrotoxicity, Levobupivacaine, Local anesthetic
  • Erciyes University Affiliated: Yes

Abstract

Background: A single dose injection or continuous infusion of local anesthetics into the joint space is considered to be a well-defined analgesia technique. The aim of this study was to investigate the chondrotoxic and apoptotic effects of single-dose intra-articular injection of levobupivacaine and bupivacaine on rabbit knee joint tissues.