Phenylketonuria With Acute Myeloblastic Leukemia in a 9-year-old Boy: Reporting a Rare Case


PATIROĞLU T., ÜNAL E., KARDAŞ F., Ozdemir M. A., KARAKÜKCÜ M., Sayilmaz O.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.33, sa.6, 2011 (SCI-Expanded) identifier identifier identifier

Özet

Phenylketonuria is a genetic metabolic disorder resulting in phenylalanine accumulation in blood. Phenylacetate, which is an abnormal phenylalanine metabolities, was hypothesized to have anticancer activity. Two-years-old boy was diagnosed with classical phenylketonuria because of mental motor retardation. When the patient was 9-year-old, he developed acute myeloblastic leukemia. Here, we present the case with phenylketonuria and acute myeloblastic leukemia because of its extreme rarity.
Phenylketonuria is a genetic metabolic disorder resulting in phenylalanine accumulation in blood. Phenylacetate, which is an abnormal phenylalanine metabolities, was hypothesized to have anticancer activity. Two-years-old boy was diagnosed with classical phenylketonuria because of mental motor retardation. When the patient was 9-year-old, he developed acute myeloblastic leukemia. Here, we present the case with phenylketonuria and acute myeloblastic leukemia because of its extreme rarity. PMID:21792031[PubMed - indexed for MEDLINE]