Phenylketonuria With Acute Myeloblastic Leukemia in a 9-year-old Boy: Reporting a Rare Case

PATIROĞLU T., ÜNAL E., KARDAŞ F., Ozdemir M. A., KARAKÜKCÜ M., Sayilmaz O.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.33, sa.6, 2011 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1097/mph.0b013e31821816cf
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: acute myeloblastic leukemia, child, phenylketonuria
  • Erciyes Üniversitesi Adresli: Evet

Özet

Phenylketonuria is a genetic metabolic disorder resulting in phenylalanine accumulation in blood. Phenylacetate, which is an abnormal phenylalanine metabolities, was hypothesized to have anticancer activity. Two-years-old boy was diagnosed with classical phenylketonuria because of mental motor retardation. When the patient was 9-year-old, he developed acute myeloblastic leukemia. Here, we present the case with phenylketonuria and acute myeloblastic leukemia because of its extreme rarity.
Phenylketonuria is a genetic metabolic disorder resulting in phenylalanine accumulation in blood. Phenylacetate, which is an abnormal phenylalanine metabolities, was hypothesized to have anticancer activity. Two-years-old boy was diagnosed with classical phenylketonuria because of mental motor retardation. When the patient was 9-year-old, he developed acute myeloblastic leukemia. Here, we present the case with phenylketonuria and acute myeloblastic leukemia because of its extreme rarity. PMID:21792031[PubMed - indexed for MEDLINE]