Effect of Wrestling Exercise on Oxidative DNA Damage, Nitric Oxide level and Paraoxonase Activity in Adolescent Boys

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Hamurcu Z. , SARITAŞ N., Başkol G. , Akpınar N.

PEDIATRIC EXERCISE SCIENCE, vol.22, no.1, pp.60-68, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1123/pes.22.1.60
  • Page Numbers: pp.60-68


The objective of the current study is to determine the effects of regular wrestling exercise oxidative DNA damage and antioxidant parameters. The findings of the current study have shown that 8-hydroxy-2'-deoxyguanosine (8-OHdG) obtained from wrestlers in basal status were significantly lower than those of sedentary (p = .001). In contrast, Nitric oxide (NO) and Paraoxonase-1 (PON1) were remarkably higher in wrestlers in basal status than those of sedentary (respectively, p = .001, p = .024). While the NO of wrestlers increased immediately after a 1.5-h exercise compared with those before exercise (p = .002), no differences was found between before and immediately after a 1.5-h exercise in 8-OHdG and PON1 (respectively, p = .777, p = .408). Statistically significant correlations were found between the NO and PON1 in the wrestlers in basal status (r = .671, p = .002). In conclusion, our study suggests that wrestling exercise for a healthy life is important in that it reduces DNA damage as well as enhancing antioxidant parameters.