Two rare PROX1 variants in patients with lymphedema


Ricci M., Amato B., Barati S., Compagna R., Veselenyiova D., Kenanoglu S., ...More

MOLECULAR GENETICS & GENOMIC MEDICINE, vol.8, no.10, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.1002/mgg3.1424
  • Title of Journal : MOLECULAR GENETICS & GENOMIC MEDICINE

Abstract

Background: The PROX1 gene is specifically expressed in a subpopulation of endothelial cells that, by budding and sprouting, give rise to the lymphatic system. It also plays a critical role in neurogenesis and during development of many organs, such as the eye lens, liver, and pancreas.