Evaluation of coagulation and fibrinolytic parameters in adult onset GH deficiency and the effects of GH replacement therapy: A placebo controlled study

Cakir I., TANRIVERDİ F., Karaca Z. C., KAYNAR L., ESER B., ÜNLÜHİZARCI K., ...Daha Fazla

GROWTH HORMONE & IGF RESEARCH, cilt.22, sa.1, ss.17-21, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.ghir.2011.12.001
  • Dergi Adı: GROWTH HORMONE & IGF RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.17-21
  • Anahtar Kelimeler: Growth hormone deficiency, Coagulation, Protein S, Natural anticoagulants, PROTEIN-S DEFICIENCY, GROWTH-HORMONE DEFICIENCY, PLASMINOGEN-ACTIVATOR INHIBITOR, CARDIOVASCULAR RISK-FACTORS, LONG-TERM TREATMENT, HYPOPITUITARY ADULTS, INCREASED PREVALENCE, ADHESION MOLECULES, DISEASE, THROMBOSIS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: Increased cardiovascular mortality/morbidity observed in patients with hypopituitarism is ascribed to growth hormone deficiency (GHD) because of its unfavorable cardiovascular risk profile. Abnormalities in the coagulation system may also contribute to increased cardiovascular morbidity/mortality. To get a better insight into the role of hemostasis in GHD we assessed several hemostatic markers at baseline and after 6 months of GH replacement therapy (GHRT).