Antimicrobial properties and DNA interactions studies of 3-hetarylazoquinoline-2,4-diol compounds

ÖZTÜRK F., AÇIK L., Sener I., Karci F., Kilic E.

TURKISH JOURNAL OF CHEMISTRY, cilt.36, sa.2, ss.293-302, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3906/kim-1107-14
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.293-302
  • Anahtar Kelimeler: Quinoline-2,4-diol, azo dye, antimicrobial property, DNA interaction, BIOLOGICAL EVALUATION, DERIVATIVES, DYES, COMPLEXES, CHEMISTRY, MECHANISM, BINDING, DRUGS
  • Erciyes Üniversitesi Adresli: Evet

Özet

The purpose of the present study was to evaluate the antimicrobial effects of 3-hetarylazoquinoline-2,4-diols (19), having substituted or unsubstituted thiazole, benzothiazole, benzimidazole, triazole, isoxazole, and thiadiazole moieties at the 3-position, on bacterial and yeast strains. In addition, compounds and DNA interaction with pUC18 plasmid DNA were studied. The biological effects of these molecules were compared with potential antibiotics ampicillin, chloramfenicol (for bacteria), and ketoconozole (for yeast). According to the results, all compounds except 8 have mild to moderate activity against some of the bacterial strains tested, and none of the compounds have activity against the fungi C. tropicalis and C. albicans. Compounds 1 and 6 have moderate activities against B. cereus and B. subtilis, and compounds 5 and 6 have moderate activities and 1 has mild activity against E. coli. Compound 2 has a mild effect on all bacterial strains except E. coli ATCC 25922, P. vulgaris, and S. aureus. Compounds 3-5 and 7 have mild activity against some of the bacterial strains tested. Compound 9 has mild activity against all bacterial strains except E. coli ATCC 25922. Compound 8 has no antibacterial effect.