Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy

Elkan P. N., Pierce S. B., Segel R., Walsh T., Barash J., Padeh S., ...Daha Fazla

NEW ENGLAND JOURNAL OF MEDICINE, cilt.370, sa.10, ss.921-931, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 370 Sayı: 10
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1056/nejmoa1307362
  • Dergi Adı: NEW ENGLAND JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.921-931
  • Erciyes Üniversitesi Adresli: Evet

Özet

BackgroundPolyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified six families with multiple cases of systemic and cutaneous polyarteritis nodosa, consistent with autosomal recessive inheritance. In most cases, onset of the disease occurred during childhood.