Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years

ÇINAR M. U., Schneider D. A., Waldron D. F., O'Rourke K. I., White S. N.

VETERINARY JOURNAL, vol.233, pp.19-24, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 233
  • Publication Date: 2018
  • Doi Number: 10.1016/j.tvjl.2017.12.019
  • Journal Name: VETERINARY JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.19-24
  • Keywords: Caprine, Disease resistance, Experimental inoculation, Prion, Transmissible spongiform encephalopathy, PROTEIN GENE POLYMORPHISMS, CODON 146, SHEEP, RESISTANCE, IDENTIFICATION, ASSOCIATION, INFECTION, VARIANTS, BREEDS, HERDS
  • Erciyes University Affiliated: No

Abstract

Scrapie is a transmissible spongiform encephalopathy of sheep and goats, and scrapie eradication programs in many parts of the world rely on strong genetic resistance to classical scrapie in sheep. However, the utility of putative resistance alleles in goats has been a focus of research because goats can transmit scrapie to sheep and may serve as a scrapie reservoir. Prior work showed that disease-free survival time was significantly extended in orally inoculated goats singly heterozygous for prion amino acid substitutions 5146 or K222, but average durations were only around 3 years post-inoculation. The aim of this study was to investigate whether extended survival would exceed 6 years, which represents the productive lifetimes of most commercial goats.