Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study.

SOLMAZ I., ÖZDEMİR M. A., ÜNAL E., Abdurrezzak Ü., Muhtaroglu S., KARAKÜKCÜ M.

Journal of pediatric endocrinology & metabolism : JPEM, vol.34, no.4, pp.441-447, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1515/jpem-2020-0637
  • Journal Name: Journal of pediatric endocrinology & metabolism : JPEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.441-447
  • Keywords: acute lymphoblastic leukemia, bone metabolism, menaquinone, osetocalcin, vitamin K2
  • Erciyes University Affiliated: Yes


Objectives: Current treatment protocols in acute lymphoblastic leukemia (ALL) are associated with high remission rates and long life expectancy, enhancing the importance of quality of life and prevention of treatment-related complications in patient care. As osteoporosis is a frequent complication in patients under chemotherapy, we investigated the effect of vitamin K2 (100 mcg menaquinone-7) and vitamin D3 (10 mcg calcitriol) on bone metabolism in children with ALL.