Diğer, ss.678-683, 2020
Objective: Rhamnetin, a flavanol, is in the subclasses of the flavonoids existing in plants. The antioxidant properties of
several plants containing flavonoids have been extensively studied in several diseases including cancer. This study
investigated the effects of rhamnetin on tumor masses, oxidant and antioxidant status in the livers of mice bearing
Ehrlich solid tumor.
Material and Methods: Fifty male Balb/C mice weighing 25-30 g were used in the study. Ten mice were kept for
Ehrlich ascites tumor (EAT) cells production and the remaining mice were randomly assigned to four groups containing
10 mice in each as healthy control and treatments receiving 1x106 EAT cells and EAT cells plus 100 µg/kg/day or 200
µg/kg/day rhamnetin via subcutaneous route. The tumor inhibition rates of rhamnetin treatments were calculated. The
livers were analyzed for malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels.
Results: Compare to tumor control, both levels of rhamnetin suppressed tumor masses throughout the experiment. The
MDA levels were increased whereas SOD and CAT activities were reduced by EAT cells injection in the liver of mice.
The 100 µg/kg/day rhamnetin treatment decreased MDA level but 200 µg/kg/day rhamnetin had no significant effect on
increased MDA level. The reduced liver SOD (p<0.001) and CAT (p<0.01) activities were elevated by both levels of
Conclusions: The results of this study have revealed that rhamnetin suppresses tumor progression and improves
antioxidant status in the livers of solid tumor-bearing mice.
Key words: Ehrlich solid tumor, lipid peroxidation, antioxidant enzymes, rhamnetin