Akademik Veri Yönetim Sistemi
HONG KONG JOURNAL OF PAEDIATRICS, cilt.24, sa.1, ss.3-8, 2019 (SCI-Expanded)
Aim: The aim of the present study was to evaluate the associations between infant feeding modalities and metabolic risk factors for urolithiasis in infants. Patients and Methods: A total of 70 infants (<12 months) with urolithiasis were included in the present study. Patients with chronic disease or anatomic abnormalities were excluded. A questionnaire was completed by the mothers. Dietary characteristics (breast and/or formula feeding, plus water supplementation) and family history of urolithiasis were determined. Patients underwent 24-h urine collection via an urethral catheter for analysis of metabolic risk factors for urolithiasis. Results: The mean age at diagnosis of stone disease was 4.47 +/- 2.41 months. The major clinical symptoms of the patients were restlesness (45.7%) and vomiting (14.3%); however, 24% of infants were asymptomatic. The majority of patients (64.2%) were solely breastfed and the remaining were given formula to supplement breastfeeding. Twenty-four of the 70 patients were supplied with water. Fifty patients (71.4%) had microlithiasis. At least one metabolic abnormality was found in 90% of the patients. Hypercalciuria and hyperuricosuria were detected in 40% and 47% of the patients, respectively. No effects of water supplementation on urinary metabolite excretion were found. Higher urinary phosphorus and uric acid excretion were detected in patients who were given formula to supplement breastfeeding. Conclusion: Urolithiasis in infancy remains a serious problem in Turkey. Infants with urolithiasis may present with nonspecific symptoms. A positive family history of urolithiasis and formula feeding was associated with increased occurence of urolithiasis in infants.