Plasma apelin level in patients with restless legs syndrome and its association with periodic leg movements

Korkmaz S., Aksu M., BAŞKOL G.

SLEEP AND BREATHING, vol.21, no.1, pp.19-24, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1007/s11325-016-1355-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.19-24
  • Erciyes University Affiliated: Yes


Apelin is an antioxidant and anti-inflammatory molecule secreted by adipose tissue and has a protective effect on cardiac and neuronal tissue. Recent studies have reported that the risk of vascular disease is increased in restless legs syndrome (RLS). We aimed to measure plasma levels of apelin in patients with RLS. Additionally, we wanted to determine if there is any relationship between apelin levels and RLS disease severity and the periodic leg movement index (PLMI).