Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials


Bhala N., Emberson J., Merhi A., Abramson S., Arber N., Baron J. A. , ...More

LANCET, vol.382, no.9894, pp.769-779, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 382 Issue: 9894
  • Publication Date: 2013
  • Doi Number: 10.1016/s0140-6736(13)60900-9
  • Title of Journal : LANCET
  • Page Numbers: pp.769-779

Abstract

Background The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at increased risk of vascular disease. We aimed to provide such information through meta-analyses of randomised trials.