Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

Bhala, N.; Emberson, J.; Merhi, A.; Abramson, S.; Arber, N.; Baron, J.; Bombardier, C.; Cannon, C.; Farkouh, M.; FitzGerald, G.; Goss, P.; Halls, H.; Hawk, E.; Hawkey, C.; Hennekens, C.; Hochberg, M.; Holland, L.; Kearney, P.; Laine, L.; Lanas, A.; Lance, P.; Laupacis, A.; Oates, J.; Patrono, C.; Schnitzer, T.; Solomon, S.; Tugwell, P.; Wilson, K.; Wittes, J.; Baigent, C.; Adelowo, O.; Aisen, P.; Al-Quorain, A.; Altman, R.; Bakris, G.; Baumgartner, H.; Bresee, C.; Carducci, M.; Chang, D-M.; Chou, C-T.; Clegg, D.; Cudkowicz, M.; Doody, L.; El Miedany, Y.; Falandry, C.; Farley, J.; Ford, L.; GarciLosa, M.; Gonzalez-Ortiz, M.; Haghighi, M.; Hala, M.; Iwama, T.; Jajic, C.; Kerr, D.; Kim, H-S.; Kohne, C.; Koo, B-K.; Martin, B.; Meinert, C.; Muller, N.; Myklebust, G.; Neustadt, D.; Omdal, R.; Ozgocmen, Salih; Papas, A.; Patrignani, P.; Pelliccia, F.; Roy, V.; Schlegelmilch, I.; Umar, A.; Wahlstrom, O.; Wollheim, F.; Yocum, S.; Zhang, X.; Hall, E.; McGettigan, P.; Midgley, R.; Moore, R.; Philipson, R.; Curtis, S.; Reicin, A.; Bond, J.; Moore, A.; Essex, M.; Fabule, J.; Morrison, B.; Tive, L.; Davies, K.; Holland, L.; Merhi, A.; Yau, F.

doi:10.1016/s0140-6736(13)60900-9

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

Bhala N., Emberson J., Merhi A., Abramson S., Arber N., Baron J. A. , ...More

LANCET, vol.382, no.9894, pp.769-779, 2013 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 382 Issue: 9894
Publication Date: 2013
Doi Number: 10.1016/s0140-6736(13)60900-9
Title of Journal : LANCET
Page Numbers: pp.769-779

Abstract

Background The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at increased risk of vascular disease. We aimed to provide such information through meta-analyses of randomised trials.