Empty Sella may be the Final Outcome in Lymphocytic Hypophysitis

Karaca Z. C., TANRIVERDİ F., ÜNLÜHİZARCI K., Kelestimur F., DÖNMEZ H.

ENDOCRINE RESEARCH, cilt.34, ss.10-17, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/07435800902841306
  • Dergi Adı: ENDOCRINE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.10-17
  • Anahtar Kelimeler: Lymphocytic Hypophysitis, Empty Sella, AUTOIMMUNE HYPOPHYSITIS, DIABETES-INSIPIDUS, ADENOHYPOPHYSITIS, INFUNDIBULONEUROHYPOPHYSITIS, DIAGNOSIS, DISEASE
  • Erciyes Üniversitesi Adresli: Evet

Özet

Introduction. Lymphocytic hypophysitis (LH) is an autoimmune disorder associated with the infiltration of the pituitary gland by lymphocytes leading to different degrees of hypopituitarism. Females are affected more frequently than males and the disease is usually associated with pregnancy or postpartum period. Case. We present a case of LH who was first diagnosed with diabetes insipidus and hyperprolactinemia. In the follow-up, the patient developed growth hormone, gonadotropin, and thyroid stimulating hormone deficiency. The typical appearance of increased stalk thickness and diffuse homogenous contrast enhancement of pituitary on magnetic resonance imaging resulted in empty sella by time. Conclusion. The present case demonstrates the natural course of LH over a 13-year period in which the empty sella was the final outcome.