The effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: a rat model


Gunturk I., Yazıcı C. , Kose K., Dagli F., Yucel B., Yay A. H.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.49, ss.1789-1799, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 49
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3906/sag-1903-225
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.1789-1799

Özet

Background/Aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration is associated with numerous side effects. Of those, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative stress and inflammation are probably the most important mechanisms that contribute to the nephrotoxicity. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent. In the present study, the effects of NAC on cisplatin-induced nephrotoxicity were investigated.