Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T-mentagrophytes by using a microdilution assay

KOC A., Silici S., AYANGIL D., FERAHBAS A., Çankaya S.

MYCOSES, vol.48, no.3, pp.205-210, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1439-0507.2005.01128.x
  • Journal Name: MYCOSES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.205-210
  • Keywords: dermatophytes, propolis, antifungal activity, antifungal agents, microdilution method, PHARMACOKINETIC PROPERTIES, ANTIBACTERIAL ACTIVITY, BROTH MACRODILUTION, SUSCEPTIBILITY, TERBINAFINE, CANDIDA, DERMATOPHYTES, ITRACONAZOLE, MULTICENTER, MYCOSES
  • Erciyes University Affiliated: Yes

Abstract

The in vitro activities of propolis against 29 strains of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, and fluconazole. Minimal inhibitory concentrations (MICs) were determined according to a National Committee for Clinical Laboratory Standards broth microdilution method. Among the systemic antifungals tested, terbinafine was the most potent. Propolis showed important antifungal activity and it merits further investigation as a potentially useful agent for the treatment of dermatophytosis.