Fruticulture is a prominent component of Brazilian agriculture. Studies have shown that climatic variability and its impact on the physiological development of plant species are fundamental for planning the agricultural calendar, resource conservation, and sustainable management of production. In this context, one of the first criterion for planting a crop is agroclimatic zoning, since it provides information on climate-related risks and aids decision-making and agricultural planning. The objective of this study was to carry out climatic risk zoning for avocado (Persea americana Mill.) in the basin of Parana River III, Parana State, Brazil. Meteorological data from 43 stations, from 1976 to 2018, were used. The climatic risk analysis was based on the requirements of the avocado for precipitation, water balance, average annual temperature, and frost tolerance. Statistical and geoprocessing techniques ensured full regional coverage of data and contributed to decision-making. The results identified favorable climatic conditions for all climatic variables in the western part of the river basin. Despite water deficits in some months, rainfall and water balance were not restrictive for avocado production in the region. Avocado tree cultivation is not recommended in the eastern part of the basin, where there is a considerable risk of frost.