Tranexamic acid has positive effect in early period of tenaon healing by stimulating the tumor necrosis factor-alpha and matrix metalloproteinase-3 expression levels

ÇIRAKLI A., Gurgor P. N., UZUN E., ERDEM H., Sahin A. A., BAŞ O.

JOINT DISEASES AND RELATED SURGERY, cilt.31, sa.3, ss.463-469, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5606/ehc.2020.74265
  • Dergi Adı: JOINT DISEASES AND RELATED SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.463-469
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objectives: This study aims to evaluate the effect of tranexamic acid (TXA) application in tendon healing by using its immunohistochemical effects on tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-3 (NIMP-3), and transforming growth factor-beta (TGF-beta) expression; and to identify if TNF-alpha, MMP-3, and TOF-beta can be used to monitor and evaluate tendon healing or not in tenotomized rat Achilles tendons.