Tranexamic acid has positive effect in early period of tenaon healing by stimulating the tumor necrosis factor-alpha and matrix metalloproteinase-3 expression levels

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ÇIRAKLI A., Gurgor P. N., UZUN E., ERDEM H., Sahin A. A., BAŞ O.

JOINT DISEASES AND RELATED SURGERY, vol.31, no.3, pp.463-469, 2020 (SCI-Expanded, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 31 Issue: 3
• Publication Date: 2020
• Doi Number: 10.5606/ehc.2020.74265
• Journal Name: JOINT DISEASES AND RELATED SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.463-469
• Erciyes University Affiliated: Yes

Abstract

Objectives: This study aims to evaluate the effect of tranexamic acid (TXA) application in tendon healing by using its immunohistochemical effects on tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-3 (NIMP-3), and transforming growth factor-beta (TGF-beta) expression; and to identify if TNF-alpha, MMP-3, and TOF-beta can be used to monitor and evaluate tendon healing or not in tenotomized rat Achilles tendons.