Anticancer activities of various new metal complexes prepared from a Schiff base on A549 cell line
INORGANIC CHEMISTRY COMMUNICATIONS, cilt.111, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 111
- Basım Tarihi: 2020
- Doi Numarası: 10.1016/j.inoche.2019.107645
- Dergi Adı: INORGANIC CHEMISTRY COMMUNICATIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, DIALNET
- Anahtar Kelimeler: Anticancer, Cytotoxic activity, Pyrimidine, Schiff base, Transition metal, ANTICONVULSANT, DERIVATIVES, CU(II), DESIGN, NI(II)
- Erciyes Üniversitesi Adresli: Evet
Özet
In this study, a new compound namely 1-((2-hydroxynaphthalen-1-yl)methyleneamino)-5-(4-methybenzoyl)-4-p-tolylpyrimidin-2(1H)-one (S2) was synthesized as a Schiff base using 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl)pyrimidin-2(1H)-one (S1) with 2-hydroxy-1-naphthaldehyde in 80% yield. Then, eight novel metal complexes (S3-S10) including Ni(II), Cu(II), Co(II), Ag(I), Pd(II), Pt(II), Cr(III), and Mn(II) metal ions were prepared from this new Schiff base (S2). The characterization of these complexes was done using H-1 NMR, C-13 NMR, LC-MS, IR, magnetic susceptibility and conductivity measurements. The anticancer activities of compounds (S3-S10) were tested against human epithelial lung carcinoma cell line (A549) for 72 h. All complexes demonstrated antiproliferative activity in A549 cell line and low half-maximal inhibitory concentration (IC50) values were calculated with GraphPad Prism program.